Key result
Left bundle branch area pacing was temporally associated with the development of Takotsubo syndrome and dynamic left ventricular outflow tract obstruction in an 81-year-old woman.
This author reply discusses the temporal relationship between left bundle branch area pacing, dynamic LVOTO, and Takotsubo syndrome in a patient with a sigmoid septum.
We thank Dr. Yalta et al. for their thoughtful Letter to the Editor regarding our report of Takotsubo syndrome (TTS) complicated by dynamic left ventricular outflow tract obstruction (LVOTO) following left bundle branch area pacing (LBBAP) in an 81-year-old woman with a sigmoid septum1. We agree that the temporal relationship among LBBAP, LVOTO, and TTS raises intriguing mechanistic questions. Baseline echocardiography showed no resting intraventricular gradient, whereas LVOTO was documented only after symptom onset, when a new grade III/VI systolic murmur and acute heart failure developed.
No takes yet. Share an insight, caveat, or question.
Pastori et al. (2026) conducted a letter in Takotsubo syndrome complicated by left ventricular outflow tract obstruction (n=1). Left bundle branch area pacing (LBBAP) was evaluated on Development of Takotsubo syndrome and left ventricular outflow tract obstruction. Left bundle branch area pacing was temporally associated with the development of Takotsubo syndrome and dynamic left ventricular outflow tract obstruction in an 81-year-old woman.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: