August 2, 2025

Supplementary Fig.S6 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

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MAIN FINDING: This study characterizes the timing of somatic mutations in lung adenocarcinoma, uncovering its evolutionary trajectory.
KEY EVIDENCE: The analysis uses a negative binomial mixed-effect model to assess how tumor mutational burden varies with smoking pack-years.
APPROACH: The research investigates clonal mutations in lung cancer among Chinese patients, emphasizing their relationship with smoking history.
SIGNIFICANCE: Understanding mutation timing can guide treatment strategies and research in lung adenocarcinoma, given its cancer evolution insights.

Implication

Negative binomial mixed-effect model indicates the relationship between tumor mutational burden and smoking pack-years in lung adenocarcinoma.

Abstract

Negative binomial mixed-effect model to test the non-linearity of the tumor mutational burden (TMB) of early and late clonal mutations with smoking pack-years.

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Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01ad https://doi.org/10.1158/0008-5472.29760715

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Implication

Negative binomial mixed-effect model indicates the relationship between tumor mutational burden and smoking pack-years in lung adenocarcinoma.

Abstract

Negative binomial mixed-effect model to test the non-linearity of the tumor mutational burden (TMB) of early and late clonal mutations with smoking pack-years.

Supplementary Fig.S6 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Fig.S6 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

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