August 2, 2025

Figure S9 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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MAIN FINDING: Tumor ifnb1 expression after treatment with 225Ac-NM600+ICI remains unchanged despite STING loss.
KEY EVIDENCE: The results show that STING expression in either tumor cells or hosts does not influence ifnb1 levels.
APPROACH: The study examined the impact of clinically relevant radionuclides on anti-tumor immune response mechanisms.
SIGNIFICANCE: Understanding these effects could improve the design and efficacy of radiopharmaceuticals in cancer therapy.

Implication

Observations reveal that radionuclide half-life and energy transfer impact the IFN1 response, suggesting implications for radiopharmaceutical use in tumors.

Abstract

Tumor Ifnb1 expression following 225Ac-NM600+ICI is not affected by loss of STING expression in tumor or host.

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Cite This Study

Kerr et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01af https://doi.org/10.1158/2326-6066.29760731

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Implication

Observations reveal that radionuclide half-life and energy transfer impact the IFN1 response, suggesting implications for radiopharmaceutical use in tumors.

Abstract

Tumor Ifnb1 expression following 225Ac-NM600+ICI is not affected by loss of STING expression in tumor or host.

Figure S9 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S9 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

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