August 2, 2025

Figure S6 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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Radionuclides like 90Y, 177Lu, and 225Ac affect the IFN1 response in the tumor microenvironment.
Changes in tumor immune cell composition are linked to the half-life of radionuclides used.
The study analyzes the effects of linear energy transfer on antitumor efficacy in radiopharmaceuticals.
Understanding these relationships may improve targeted therapies for better cancer management.

Implication

Research shows radionuclide half-life and energy transfer influence the IFN1 response in tumors, suggesting implications for treatment.

90Y-, 177Lu, 225Ac-NM600 modulate tumor immune cell composition in the tumor microenvironment.

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Kerr et al. (2025) studied this question.

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Research shows radionuclide half-life and energy transfer influence the IFN1 response in tumors, suggesting implications for treatment.

90Y-, 177Lu, 225Ac-NM600 modulate tumor immune cell composition in the tumor microenvironment.