August 2, 2025

Figure S5 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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The study investigates how radionuclides affect the interferon response and their antitumor efficacy.
Findings indicate a correlation between radionuclide half-life, linear energy transfer, and gene expression changes.
Methods include in vivo testing with 12 Gy EBRT to assess treatment impact on gene activity.
Understanding these effects could lead to improved strategies in radiopharmaceutical therapies for cancer.

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Longitudinal analysis reveals how radionuclide half-life and energy transfer influence the interferon response and treatment effectiveness.

Longitudinal in vivo gene expression following 12 Gy EBRT (MOC2).

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Kerr et al. (2025) studied this question.

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Longitudinal analysis reveals how radionuclide half-life and energy transfer influence the interferon response and treatment effectiveness.

Longitudinal in vivo gene expression following 12 Gy EBRT (MOC2).