August 2, 2025

Figure S3 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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MAIN FINDING: Radionuclide half-life and linear energy transfer significantly influence the IFN1 response in tumor cells.
KEY EVIDENCE: Expression levels of Ifnb1, Mx1, and other immune markers were analyzed following different EBRT doses.
APPROACH: The study used in vitro models to assess the impact of varying radiation doses on gene expression related to immune response.
SIGNIFICANCE: These findings enhance understanding of how radionuclides can optimize radiopharmaceutical therapies for cancer treatment.

Implication

Longitudinal analysis reveals the correlation between radionuclide half-life, energy transfer, and IFN1 response in tumor cells, suggesting implications for therapy.

Abstract

Longitudinal Ifnb1, Mx1, Ddx58, Fas, Pdl1, and Mhc1 expression following (A) 12 Gy EBRT (MOC2) or (B) 4 Gy EBRT (B78) in vitro.

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Cite This Study

Kerr et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01b4 https://doi.org/10.1158/2326-6066.29760755

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Implication

Longitudinal analysis reveals the correlation between radionuclide half-life, energy transfer, and IFN1 response in tumor cells, suggesting implications for therapy.

Abstract

Longitudinal Ifnb1, Mx1, Ddx58, Fas, Pdl1, and Mhc1 expression following (A) 12 Gy EBRT (MOC2) or (B) 4 Gy EBRT (B78) in vitro.

Figure S3 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S3 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

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