August 2, 2025

Figure S2 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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The study shows that radionuclide properties significantly influence the IFN1 response to radiation.
Early induction of the immunologic response was observed particularly with 58mCo and 119Sb radionuclides.
The researchers examined how the half-life and linear energy transfer of radionuclides affected antitumor efficacy.
These findings suggest optimizing radionuclide selection could enhance the effectiveness of radiopharmaceutical therapies.

Implication

Experiments reveal earlier IFN1 response in radiopharmaceuticals, suggesting half-life and energy transfer play critical roles.

Earlier induction of type I IFN response/immunologic response to radiation following 58mCo and 119Sb.

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Kerr et al. (2025) studied this question.

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Experiments reveal earlier IFN1 response in radiopharmaceuticals, suggesting half-life and energy transfer play critical roles.

Earlier induction of type I IFN response/immunologic response to radiation following 58mCo and 119Sb.