August 2, 2025

Figure S4 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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Core finding demonstrates that radionuclide characteristics influence the IFN1 response in cancer cells.
Comparison shows higher levels of γH2AX foci in MOC2 and B78 cells after exposure to different radionuclides.
Methodology includes assessing responses of cells to external beam radiation therapy and various radionuclides.
Results indicate that understanding these relationships could enhance the development of effective radiopharmaceuticals.

Implication

Experimental analysis reveals the relation of IFN1 response to radionuclide half-life and energy transfer in radiopharmaceutical efficacy.

Representative images of γH2AX foci over time in (A) MOC2 (12 Gy) and (B) B78 (4 Gy) cells following EBRT, 90Y, 177Lu, and 225Ac.

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Kerr et al. (2025) studied this question.

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Experimental analysis reveals the relation of IFN1 response to radionuclide half-life and energy transfer in radiopharmaceutical efficacy.

Representative images of γH2AX foci over time in (A) MOC2 (12 Gy) and (B) B78 (4 Gy) cells following EBRT, 90Y, 177Lu, and 225Ac.