August 2, 2025

Figure S8 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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MAIN FINDING: Radionuclides significantly influence the activation of the IFN1 response in tumors.
KEY EVIDENCE: Activation levels correlate with both the half-life and linear energy transfer of the radionuclides.
APPROACH: Individual tumor growth curves from Figure 6F were analyzed to assess these effects.
SIGNIFICANCE: Understanding these correlations can enhance the efficacy of radiopharmaceutical treatments in cancer therapy.

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This analysis shows how radionuclides impact IFN1 responses in tumors, suggesting a relationship with half-life and energy transfer.

Individual tumor growth curves from Figure 6F.

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Kerr et al. (2025) studied this question.

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This analysis shows how radionuclides impact IFN1 responses in tumors, suggesting a relationship with half-life and energy transfer.

Individual tumor growth curves from Figure 6F.