August 2, 2025

Figure S7 from The Effects of Clinically Relevant Radionuclides on the Activation of an IFN1 Response Correlate with Radionuclide Half-life and Linear Energy Transfer and Influence Radiopharmaceutical Antitumor Efficacy

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MAIN FINDING: Radionuclide half-life significantly influences the activation of an IFN1 response in cell lines.
KEY EVIDENCE: Gene expression levels of Ifnb1 and Ddx58 were upregulated after treatment with 225Ac or EBRT.
APPROACH: The study utilized B78 WT and STING KO cell lines to observe differences in responses.
SIGNIFICANCE: Understanding the role of linear energy transfer could enhance the efficacy of radiopharmaceuticals in cancer therapy.

Implication

In vitro analysis shows radionuclide half-life impacts IFN1 response and radiopharmaceutical effectiveness.

B78 WT vs. STING KO cell line in vitro Ifnb1 and Ddx58 gene expression upregulation following 225Ac or EBRT.

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Kerr et al. (2025) studied this question.

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In vitro analysis shows radionuclide half-life impacts IFN1 response and radiopharmaceutical effectiveness.

B78 WT vs. STING KO cell line in vitro Ifnb1 and Ddx58 gene expression upregulation following 225Ac or EBRT.