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August 1, 2025

Supplementary figure S12 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li Jason W. Shapiro Hardik Shah Emily F. Higgs Lishi Xie Yaopeng Li Yuanyuan Zha Jonathan Trujillo Alexandra Cabanov Tyler A. Jones Blake Flood Ken Hatogai Ruxandra Tonea Justin Kline Thomas F. Gajewski

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Key Points

MAIN FINDING: Decr2 plays a significant role in regulating ferroptosis in tumor cells.
KEY EVIDENCE: Flow cytometry identifies changes in lipid reactive oxygen species linked to therapy responses.
APPROACH: Flow cytometry was employed to analyze reactive oxygen species in tumor cell samples.
SIGNIFICANCE: Understanding Decr2's role may enhance immunotherapy effectiveness in combating tumors.

Implication

Flow cytometry analysis reveals lipid reactive oxygen species in tumor cells, suggesting insights for immunotherapy efficacy.

Abstract

Supplementary Figure S12. The gating strategy for flow cytometry analysis of lipid reactive oxygen species (ROS).

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d023e https://doi.org/10.1158/2326-6066.29760124

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S8 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
2Supplementary figure S6 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
3Supplementary figure S7 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
4Supplementary figure S16 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
5Supplementary figure S4 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025

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Supplementary figure S11 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
Supplementary figure S9 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
Supplementary figure S15 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025