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August 1, 2025

Supplementary figure S6 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li Jason W. Shapiro Hardik Shah Emily F. Higgs Lishi Xie Yaopeng Li Yuanyuan Zha Jonathan Trujillo Alexandra Cabanov Tyler A. Jones Blake Flood Ken Hatogai Ruxandra Tonea Justin Kline Thomas F. Gajewski

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Key Points

Main finding indicates the role of Decr2 in regulating ferroptosis within the tumor microenvironment.
Evidence stems from flow cytometry analysis showing distinct characteristics of the B16.SIY tumors in B6 mice.
Approach involved isolating the tumor microenvironment and employing a gating strategy for detailed analysis.
Significance lies in enhancing understanding of immunotherapy efficacy through tumor cell-intrinsic mechanisms.

Implication

Flow cytometry analysis reveals tumor microenvironment characteristics in B16.SIY mice, suggesting insights into immunotherapy efficacy.

Abstract

Supplementary Figure S6. Gating strategy for Flow cytometry analysis of B16.SIY tumor microenvironment isolated from B6 mice.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02d9 https://doi.org/10.1158/2326-6066.29760079

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S8 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
2Supplementary figure S7 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
3Supplementary figure S12 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
4Supplementary figure S4 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
5Supplementary figure S17 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025

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Supplementary figure S5 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025