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August 1, 2025

Supplementary figure S8 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li Jason W. Shapiro Hardik Shah Emily F. Higgs Lishi Xie Yaopeng Li Yuanyuan Zha Jonathan Trujillo Alexandra Cabanov Tyler A. Jones Blake Flood Ken Hatogai Ruxandra Tonea Justin Kline Thomas F. Gajewski

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Key Points

MAIN FINDING: Decr2 regulates ferroptosis and influences immunotherapy efficacy within tumor cells.
KEY EVIDENCE: Flow cytometry analysis of B16.SIY tumors in B6 mice shows significant cellular changes.
APPROACH: A gating strategy was utilized in flow cytometry to assess the tumor microenvironment.
SIGNIFICANCE: Understanding decr2's role could enhance immunotherapy strategies for better cancer treatment.

Implication

Flow cytometry analysis reveals tumor microenvironment characteristics in B6 mice, suggesting insights into decr2's impact on immunotherapy.

Abstract

Supplementary Figure S8. Gating strategy for Flow cytometry analysis of B16.SIY tumor microenvironment isolated from B6 mice.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02ca https://doi.org/10.1158/2326-6066.29760073

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S6 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
2Supplementary figure S7 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
3Supplementary figure S12 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
4Supplementary figure S4 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
5Supplementary figure S17 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025

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Supplementary figure S5 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025