Supplementary Figure S30 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: Elevated lgals9 in epithelial cells drives the transformation of nfs into cafs during colorectal cancer progression.
KEY EVIDENCE: Data indicate this transformation is specific to the tumorigenesis of colorectal cancer.
APPROACH: Single-cell eqtl mapping was employed to assess genetic control across cell subtypes.
SIGNIFICANCE: Results advance understanding of malignant transformation mechanisms in colorectal cancer, aiding future treatments.

Single-cell eqtl mapping reveals that elevated lgals9 in epithelial cells promotes malignant transformation of nfs into cafs in colorectal cancer.

Supplementary Figure 30 shows elevated LGALS9 in epithelial cells promotes the transformation of NFs into CAFs across CRC tumorigenesis.

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Chen et al. (2025) studied this question.

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