Supplementary Figure S32 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Main finding reveals that lgals9 is crucial for mycaf activation in colorectal cancer.
Key evidence shows that lgals9 interacts with slc1a5, driving specific genetic control mechanisms.
Approach utilized single-cell eqtl mapping to uncover subtype-specific genetic influences in cancer.
Significance lies in understanding cellular mechanisms that contribute to malignant transformation in colorectal cancer.

Single-cell eqtl mapping reveals lgals9 promotes mycaf activation by interacting with slc1a5 in colorectal cancer.

Supplementary Figure 32 shows LGALS9 promotes myCAF activation by interacting with SLC1A5.

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Chen et al. (2025) studied this question.

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