Supplementary Figure S28 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: The sc-eqtl variant rs4794979 regulates lgals9 expression in specific cell subtypes of colorectal cancer.
KEY EVIDENCE: Binding of the transcription factor ELK1 mediates the regulation of lgals9 by the rs4794979 variant.
APPROACH: Analysis used single-cell sequencing to identify genetic control mechanisms involved in malignant transformation.
SIGNIFICANCE: This research enhances understanding of how genetic factors contribute to the progression of colorectal cancer.

Single-cell eqtl mapping finds genetic regulation of lgals9 in colorectal cancer, indicating subtype-specific mechanisms.

Supplementary Figure 28 shows sc-eQTL variant rs4794979 regulates LGALS9 expression mediated by binding ELK1.

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Chen et al. (2025) studied this question.

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