Supplementary Figure S29 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: rs4794979 influences LGALS9 expression and ELK1 binding in colorectal cancer cells.
KEY EVIDENCE: Direct effects observed using CRISPR/Cas9-mediated genome editing in CRC cells demonstrate genetic control.
APPROACH: The study utilized single-cell eQTL mapping to analyze genetic influences on cell subtype-specific traits.
SIGNIFICANCE: Findings may lead to targeted interventions in malignant transformation processes of colorectal cancer.

Single-cell eQTL mapping reveals genetic effects on LGALS9 expression in colorectal cancer, suggesting new targets for intervention.

Supplementary Figure 29 shows direct effects of rs4794979 on LGALS9 expression and ELK1 binding in CRISPR/Cas9-mediated genome editing CRC cells.

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Chen et al. (2025) studied this question.

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