Supplementary Figure S34 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: LGALS9 promotes CD8+ T cell exhaustion, facilitating malignant transformation in colorectal cancer.
KEY EVIDENCE: Enhanced CRC growth observed in vivo due to LGALS9 influence on immune cell exhaustion.
APPROACH: Single-cell eQTL mapping was used to analyze genetic control mechanisms in cancer subtypes.
SIGNIFICANCE: Understanding immune evasion in colorectal cancer could lead to novel therapeutic strategies.

Single-cell eQTL mapping reveals LGALS9 induces CD8+ T cell exhaustion in colorectal cancer, suggesting new mechanisms of tumor growth.

Supplementary Figure 34 shows LGALS9 induces CD8+ T cell exhaustion to facilitate CRC growth in vivo.

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Chen et al. (2025) studied this question.

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