Supplementary Figure S31 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Can Chen; Yimin Cai; Wenlong Hu; Kai Tan; Zequn Lu; Xuanyu Zhu; Ziying Liu; Chunyi He; Guangping Xu; Ruizhe Zhang; Caibo Ning; Shuheng Ruan; Jiayan Gao; Xiaojun Yang; Yongchang Wei; Xu Zhu; Xiangpan Li; Faxi Wang; Fubing Wang; Jiaoyuan Li; Meng Jin; Bin Li; Ying Zhu; Jianbo Tian; Xiaoping Miao

doi:10.1158/2159-8290.29819616

Key Points

MAIN FINDING: Single-cell eQTL mapping reveals specific genetic control mechanisms in colorectal cancer.
KEY EVIDENCE: The study highlights the role of LGALS9 in affecting the pathological phenotype of colorectal cancer.
APPROACH: Researchers utilized single-cell analysis to investigate genetic influences on cancer transformation.
SIGNIFICANCE: Understanding these genetic controls may enhance treatment strategies for colorectal cancer patients.

Implication

Single-cell eQTL mapping demonstrates genetic control of pathological phenotypes in colorectal cancer, suggesting key mechanisms in malignant transformation.

Abstract

Supplementary Figure 31 shows the effect of LGALS9 on the pathological phenotype of CRC with or without NFs.

Discussion

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d092f https://doi.org/10.1158/2159-8290.29819616

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Supplementary Figure S31 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S31 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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