Supplementary Figure S33 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Can Chen; Yimin Cai; Wenlong Hu; Kai Tan; Zequn Lu; Xuanyu Zhu; Ziying Liu; Chunyi He; Guangping Xu; Ruizhe Zhang; Caibo Ning; Shuheng Ruan; Jiayan Gao; Xiaojun Yang; Yongchang Wei; Xu Zhu; Xiangpan Li; Faxi Wang; Fubing Wang; Jiaoyuan Li; Meng Jin; Bin Li; Ying Zhu; Jianbo Tian; Xiaoping Miao

doi:10.1158/2159-8290.29819610

Key Points

MAIN FINDING: LGALS9 promotes CD8+ T cell exhaustion, which aids in the growth of colorectal cancer (CRC).
KEY EVIDENCE: Supplementary Figure 33 demonstrates the in vitro effects of LGALS9 on T cells and CRC growth.
APPROACH: The study uses single-cell eQTL mapping to uncover genetic influences on malignant transformation in colorectal cancer.
SIGNIFICANCE: Understanding LGALS9's role provides insight into potential therapeutic targets for CRC.

Implication

Single-cell eQTL mapping reveals LGALS9's role in inducing T cell exhaustion, facilitating CRC growth in vitro, suggesting genetic control mechanisms.

Abstract

Supplementary Figure 33 shows LGALS9 induces CD8+ T cell exhaustion to facilitate CRC growth in vitro.

Discussion

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0941 https://doi.org/10.1158/2159-8290.29819610

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Supplementary Figure S33 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S33 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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