Supplementary Figure S36 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: Targeting LGALS9 synergizes with anti-PD-1 therapy to inhibit colorectal cancer growth.
KEY EVIDENCE: Supplementary figure highlights significant interaction between LGALS9 and anti-PD-1 in cancer cells.
APPROACH: Single-cell eQTL mapping was used to explore genetic control in malignant transformation.
SIGNIFICANCE: Findings could lead to more effective therapies for colorectal cancer patients by combining strategies.

Supplementary figure indicates LGALS9 targeting enhances anti-PD-1 therapy effectiveness in colorectal cancer, suggesting new treatment avenues.

Supplementary Figure 36 shows targeting LGALS9 synergizes with anti-PD-1 therapy to inhibit CRC.

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Chen et al. (2025) studied this question.

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