Supplementary Figure S26 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

CORE FINDING: Single-cell eQTL mapping identifies genetic control specific to colorectal cancer subtypes.
KEY EVIDENCE: PRS models derived from cell type-specific eQTLs effectively predict CRC risk across diverse populations.
APPROACH: Analysis of cell-specific genetic variations in colorectal cancer was performed across multi-ethnic populations.
SIGNIFICANCE: Understanding genetic factors in CRC may enhance personalized risk assessment and treatment options.

Single-cell eQTL mapping reveals genetic factors influencing colorectal cancer risk, indicating population-specific differences in prediction models.

Supplementary Figure 26 shows CRC risk prediction by PRS models derived from cell type-specific eQTLs across multi-ethnic populations.

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Chen et al. (2025) studied this question.

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