Supplementary Figure S6 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

Key Points

The c-terminal kinase domain–binding motif prevents excessive activation of FGFR2, crucial for normal signaling.
Alignments of orthologous sequences in FGFR2 reveal evolutionary conservation among various species.
The findings indicate that the suppression motif in FGFR2 is vital to regulate its activity and maintain cellular balance.
This analysis provides insights into FGFR2 regulation and its evolutionary significance across different organisms.

We only have this paper's title and publication details.

Answers are grounded in this paper and cite their sources.

Analysis reveals that the c-terminal motif suppresses FGFR2 activation by binding with orthologs and paralogs.

Alignments of C-tail sequences of Fgfr2 orthologs and human Fgfr paralogs.

No takes yet. Share an insight, caveat, or question.

Zingg et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Share