Supplementary Figure S4 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

This is a FACS study (also classified as: RNA-seq).

Key Points

The study identifies the F703-S704 motif's crucial role in FGFR2 regulation.
FACS was used to support the motif mapping, providing visual gating strategies.
RNA-seq analysis highlighted the regulatory dynamics of FGFR2 activation.
Understanding this motif may improve therapeutic strategies for FGFR2-related conditions.

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Mapping of the F703-S704 motif in FGFR2 C-tail using FACS and RNA-seq, indicating key interactions.

Data supporting the mapping of the F703–S704 motif in the Fgfr2 C-tail using FACS (gating strategy shown) and RNA-seq.

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Zingg et al. (2025) studied this question.

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