Supplementary Figure S9 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

This is a In Vitro Study study (also classified as: Animal Study).

Key Points

The fgfr2 variants demonstrated significant differences in activation levels, highlighting their functional roles.
In vitro analysis revealed that the c-terminal F703–S704 combination effectively modulates fgfr2 activity.
Utilizing both in vitro and in vivo methods provided comprehensive insights into fgfr2 regulation.
These findings suggest the necessity for further exploration of fgfr2's regulatory mechanisms in biological contexts.

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Functional analysis of fgfr2 variants was assessed in vitro and in vivo, suggesting potential regulatory mechanisms.

Data supporting the functional analysis of C-terminal F703–S704 combination Fgfr2 variants using in vitro and in vivo methods.

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Zingg et al. (2025) studied this question.

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