⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

September 2, 2025Open Access

Supplementary Figure S3 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

Daniel Zingg Chi‐Chuan Lin Julia Yemelyanenko Łukasz Wieteska Sjors M. Kas Onno B. Bleijerveld Xue Chao Jinhyuk Bhin Catrin Lutz Ellen Wientjens Sjoerd Klarenbeek Giulia Zanetti Stefano Annunziato Bjørn Siteur Eline van der Burg Anne Paulien Drenth Marieke van de Ven Lodewyk F.A. Wessels Maarten Altelaar John E. Ladbury Jos Jonkers

View Full Paper

Ask AI

Bookmark

Share

Key Points

Histological examination shows the role of FGFR2 C-tail motif variants in preventing activation.
Analysis of mammary glands highlights how C-terminal kinase domain interacts with FGFR2.
The study investigates the implications of motif variants on FGFR2 activity and signaling.
Findings support the necessity of specific motifs in regulating receptor activation.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Implication

Histological analysis reveals that C-tail motif variants impact FGFR2 activation in mammary glands.

Abstract

Histological examination of mammary glands injected with Fgfr2-E18 C-tail motif variants

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zingg et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f610 https://doi.org/10.1158/0008-5472.30029069

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S8 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
2Supplementary Figure S2 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
3Supplementary Figure S9 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
4Supplementary Figure S7 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
5Supplementary Figure S4 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
6Supplementary Figure S1 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
7Supplementary Figure S6 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
8Supplementary Figure S5 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025