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September 2, 2025Open Access

Supplementary Figure S8 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

Daniel Zingg Chi‐Chuan Lin Julia Yemelyanenko Łukasz Wieteska Sjors M. Kas Onno B. Bleijerveld Xue Chao Jinhyuk Bhin Catrin Lutz Ellen Wientjens Sjoerd Klarenbeek Giulia Zanetti Stefano Annunziato Bjørn Siteur Eline van der Burg Anne Paulien Drenth Marieke van de Ven Lodewyk F.A. Wessels Maarten Altelaar John E. Ladbury Jos Jonkers

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Key Points

Histological examination revealed significant differences in FGFR2 activation levels.
The c-terminal motif variants impact FGFR2 activation, suggesting important regulatory roles.
Mammary glands injected with FGFR2 variants showed altered histological features.
These findings emphasize the significance of the c-terminal region in FGFR2 regulation.

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Implication

Histological examination of FGFR2 motif variants in mammary glands highlights its role in activation.

Abstract

Histological examination of mammary glands injected with C-terminal F703–S704 Fgfr2 motif variants.

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Cite This Study

Zingg et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f61c https://doi.org/10.1158/0008-5472.30029054

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1Supplementary Figure S3 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
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7Supplementary Figure S6 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025
8Supplementary Figure S5 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR22025