Supplementary Figure S2 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

This is a In Vitro Study study (also classified as: Animal Study).

Key Points

The C-terminal motif of FGFR2 prevents its constitutive activation, providing insights into its regulatory mechanisms.
In vitro experiments show the importance of the C-tail motif in FGFR2 functionality, revealing potential therapeutic implications.
Data from in vivo studies corroborate the influence of the C-terminal motif on FGFR2 activation in biological systems.
Understanding the kinase domain and its binding relationship to FGFR2 may inform new strategies for targeted therapies.

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In vitro and in vivo analyses reveal the role of the C-terminal motif in FGFR2 activation, suggesting potential therapeutic insights.

Data supporting the in vitro and in vivo Fgfr2-E18 C-tail motif analyses.

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Zingg et al. (2025) studied this question.

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