Supplementary Figure S7 from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

This is a In Vitro Study study (also classified as: Animal Study).

Key Points

The c-terminal motif of FGFR2 prevents its constitutive activation, which is crucial for its functional regulation.
In vitro and in vivo methods were used to analyze the F703–S704 Fgfr2 motif, demonstrating its importance.
This research contributes to understanding FGFR2 signaling mechanisms, which are relevant in various biological contexts.
Further investigation could lead to enhanced therapeutic strategies targeting FGFR2 related pathways.

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Analysis reveals FGFR2 c-terminal motif's role in preventing activation, highlighting both in vitro and in vivo methods.

Data supporting the functional analysis of the C-terminal F703–S704 Fgfr2 motif using in vitro and in vivo methods.

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Zingg et al. (2025) studied this question.

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