Supplementary Methods from The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

Key Points

The study effectively outlines how the kinase domain-binding and suppression motif prevents FGFR2 activation, supporting cellular regulation.
Through the use of specialized FLAG and HALO tag constructs, detailed methods are provided to enhance study reproducibility.
Investigation into kinase interactions reveals crucial insights into FGFR2 modulation, opening new avenues for therapeutic strategies.
This work highlights the implications of motif-driven suppression in relationship to FGFR2, indicating its significance in cellular signaling.

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Supplementary methods detail FLAG and HALO tag constructs, revealing inhibition of FGFR2 activation.

Supplementary Methods related to FLAG and HALO tag constructs.

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Zingg et al. (2025) studied this question.

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