Supplementary Figure S2 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

Histone citrullination drives tumor progression by promoting cell proliferation and altering the tumor microenvironment.
NET formation is significantly indicated by the presence of extracellular Cit-H3 in human pancreatic cancer (PDAC).
This research highlights the potential role of PAD2 in influencing pancreatic cancer characteristics and treatment outcomes.
Understanding this mechanism may open up new therapeutic approaches targeting histone modifications in pancreatic cancer.

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Research demonstrates that histone citrullination enhances cell proliferation in pancreatic cancer, indicating significant implications for tumors.

Significance of NET formation indicated by extracellular Cit-H3 in human PDAC

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Umemura et al. (2025) studied this question.

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