Supplementary Figure S11 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Kentaro Umemura; Yoshimitsu Akiyama; Shu Shimada; Megumi Hatano; A. Kono; Koya Yasukawa; Atsushi Kamachi; Yosuke Igarashi; Shu Tsukihara; Yoshiaki Tanji; Koichiro Morimoto; Atsushi Nara; Masahiro Yamane; Keiichi Akahoshi; Hiroaki Ono; Akira Shimizu; Yuji Soejima; Minoru Tanabe; Daisuke Ban; Shinji Tanaka

doi:10.1158/1541-7786.30264244

Key Points

Tumor progression is accelerated by histone citrullination, impacting cancer cell growth and microenvironment.
Key evidence shows that the PAD2-PRUNE1 axis regulates the secretion of M2 TAM-associated proteins.
Analysis of pancreatic cancer reveals marked changes in histone modification linked to increased cell proliferation.
These findings indicate that targeting the PAD2 pathway may offer new therapeutic approaches for pancreatic cancer.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Observational analysis shows enhanced cell proliferation and altered microenvironment in pancreatic cancer, indicating PAD2-M2 TAM interaction's critical role.

Abstract

PAD2–PRUNE1 axis regulates secretion of M2 TAM–associated proteins

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Umemura et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa32bb https://doi.org/10.1158/1541-7786.30264244

View Full Paper

Ask AI

Bookmark

Share

Supplementary Figure S11 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S11 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading