Supplementary Figure S6 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Q: What type of study is this?

This is a Quantitative Study study.

Kentaro Umemura; Yoshimitsu Akiyama; Shu Shimada; Megumi Hatano; A. Kono; Koya Yasukawa; Atsushi Kamachi; Yosuke Igarashi; Shu Tsukihara; Yoshiaki Tanji; Koichiro Morimoto; Atsushi Nara; Masahiro Yamane; Keiichi Akahoshi; Hiroaki Ono; Akira Shimizu; Yuji Soejima; Minoru Tanabe; Daisuke Ban; Shinji Tanaka

doi:10.1158/1541-7786.30264229

Key Points

Histone citrullination drives tumor progression and enhances cell proliferation in pancreatic cancer.
Knockdown of PRUNE1 and macrophage depletion were shown to significantly impact tumor behavior, indicating crucial pathways.
This study employed observational analysis to investigate the effects of histone modification in a tumor microenvironment.
These findings highlight potential therapeutic strategies targeting histone citrullination and microenvironment modulation.

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Implication

Observational analysis reveals that histone citrullination enhances cell proliferation in pancreatic cancer, suggesting potential therapeutic targets.

Abstract

Effects of PRUNE1 knockdown and macrophage depletion

Discussion

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Cite This Study

Umemura et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa32c2 https://doi.org/10.1158/1541-7786.30264229

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Supplementary Figure S6 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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