Supplementary Figure S10 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

Increased PAD2 activity correlates with tumor progression, enhancing cell proliferation and altering the microenvironment.
Key findings indicate the prognostic value of PRUNE1 and CD206 in pancreatic cancer outcomes.
Transcriptome-based analysis highlights interactions between PAD2 and PRUNE1, signaling pathways involved in tumor dynamics.
Results underline the potential for PAD2 targeting in therapeutic strategies for pancreatic cancer patients.

Observational analysis reveals PAD2 correlation with PRUNE1 in pancreatic cancer, suggesting its role in modifying the tumor microenvironment.

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Umemura et al. (2025) studied this question.

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