Supplementary Figure S1 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

PAD2-mediated histone citrullination drives tumor progression in pancreatic cancer, enhancing cell proliferation and modifying the tumor microenvironment.
Significantly increased cell proliferation was noted, contributing to a more aggressive tumor phenotype, implicating PAD2's critical role.
Observational analysis of PAD2 and PAD4 expression in pancreatic ductal adenocarcinoma reveals correlations to altered tumor behavior.
These findings highlight PAD2's potential as a therapeutic target in pancreatic cancer, necessitating further studies for clinical validation.

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Analysis shows PAD2 enhances cell proliferation and modifies the microenvironment in pancreatic cancer, indicating significant tumor progression.

Expression of PAD2 and PAD4 in PDAC

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Umemura et al. (2025) studied this question.

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