Supplementary Figure S8 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Q: What type of study is this?

This is a Experimental Study study.

Kentaro Umemura; Yoshimitsu Akiyama; Shu Shimada; Megumi Hatano; A. Kono; Koya Yasukawa; Atsushi Kamachi; Yosuke Igarashi; Shu Tsukihara; Yoshiaki Tanji; Koichiro Morimoto; Atsushi Nara; Masahiro Yamane; Keiichi Akahoshi; Hiroaki Ono; Akira Shimizu; Yuji Soejima; Minoru Tanabe; Daisuke Ban; Shinji Tanaka

doi:10.1158/1541-7786.30264223

Key Points

Enhanced cell proliferation indicates that PAD-mediated mechanisms may drive tumor progression in pancreatic cancer.
PAD inhibition experiments showed significant alterations in the microenvironment associated with tumor dynamics.
Macrophage depletion experiments reveal important interactions between immune cells and tumor cells in shaping tumor behavior.
The findings suggest that targeting PAD and macrophages could be integral to therapeutic strategies in pancreatic cancer.

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Implication

Observational experiments show enhanced cell proliferation and microenvironment modification in pancreatic cancer, indicating PAD's role in tumor progression.

Abstract

PAD inhibitor and macrophage depletion experiments

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Cite This Study

Umemura et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa32d1 https://doi.org/10.1158/1541-7786.30264223

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Supplementary Figure S8 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S8 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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