Supplementary Figure S9 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Key Points

Inhibition of PAD2 significantly suppresses tumor growth in pancreatic cancer models, and reduces M2 macrophage infiltration.
PAD2 knockdown resulted in a notable decrease in the proliferation of cancer cells, leading to slower tumor progression.
Assessment utilized syngeneic PDAC models to evaluate the effects of PAD2 on tumor dynamics and microenvironmental changes.
These findings suggest targeting PAD2 could offer new avenues for therapeutic strategies against pancreatic cancer.

Inhibition of PAD2 reduces tumor growth and macrophage infiltration in pancreatic cancer models, implying potential therapeutic strategies.

Pad2 knockdown or inhibition suppresses tumor growth and M2 macrophage tumor infiltration in syngeneic PDAC models

No takes yet. Share an insight, caveat, or question.

Umemura et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Share