Supplementary Figure S7 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

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Key Points

Enhanced cell proliferation in pancreatic cancer linked to histone citrullination, driving tumor progression.
Flow cytometric analysis reveals macrophage polarization changes related to tumor microenvironment modifications.
The study utilized experimental models to assess the impact of histone citrullination on cancer cell dynamics.
Findings suggest a complex interplay between cancer cells and macrophages, highlighting new therapeutic targets in pancreatic cancer.

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Analysis shows enhanced cell proliferation and altered microenvironment in pancreatic cancer, indicating significant tumor progression mechanisms.

Flow cytometric analysis of macrophage polarization

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Umemura et al. (2025) studied this question.

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