Supplementary Figure S4 from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

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Key Points

Enhanced cell proliferation was observed in vitro when PAD2 was active in pancreatic cancer cells, indicating its role in tumor advancement.
PAD2's influence extends beyond proliferation, impacting the tumor microenvironment, which may contribute to aggressive cancer traits.
Increased histone citrullination linked to PAD2 activation suggests a potential mechanism for modifying cellular behavior in pancreatic cancer.
Finding targeted therapies addressing PAD2 could represent a crucial strategy for improving pancreatic cancer treatment options.

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In vitro analysis shows PAD2 enhances cell proliferation and modifies the microenvironment in pancreatic cancer.

Effect of PAD2 on PDAC cell proliferation in vitro

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Umemura et al. (2025) studied this question.

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