PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 4, 2026The Journal of Infectious Diseases

Severe Lower Respiratory Tract Infection in Patients With Human Bocavirus Monoinfection in Southeast China

View Full Paper
Ask AI
Bookmark
Share

Population

Children with HBoV monoinfection and critical LRTI in Southeast China

Key result

High HBoV DNA load, elevated IFN-γ, neutrophilia, and VP1_L40S variant are linked to severe lower respiratory tract infections in children with HBoV monoinfection.

Authors

LLLuona LinXCXin CongWLWei Li

Discussion

Loading...

Member takes

Overview

May warrant closer monitoring in HBoV monoinfection; extends evidence on viral and host inflammatory determinants of severity.

Key Points

  • Investigate the impact of human bocavirus (HBoV) monoinfection on severe lower respiratory tract infections (LRTI) in children in Southeast China.
  • Analyzed cases of children with confirmed HBoV monoinfection.
  • Measured DNA load, IFN-γ levels, and neutrophil counts.
  • Identified viral variants present in patients.
  • High DNA load observed in patients correlates with severe LRTI.
  • Elevated IFN-γ levels and neutrophilia were significant findings.
  • The viral VP1_L40S variant was linked to worse disease outcomes.

Structured PICO

P
Population
Children with Human Bocavirus (HBoV) monoinfection and lower respiratory tract infection (LRTI)
O
Outcome
Severe disease outcomes / critical LRTI

High DNA load, elevated IFN-γ levels, neutrophilia, and the viral VP1_L40S variant are associated with severe lower respiratory tract infection in children with HBoV monoinfection.

Cite This Study

Lin et al. (2026) studied this question. High HBoV DNA load, elevated IFN-γ, neutrophilia, and VP1_L40S variant are linked to severe lower respiratory tract infections in children with HBoV monoinfection.

synapsesocial.com/papers/69a7cce8d48f933b5eed8d24https://doi.org/10.1093/infdis/jiag024
View Full Paper
Ask AI
Bookmark
Share