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Examine the outcomes of deep brain stimulation in patients with clozapine-resistant schizophrenia.

May 4, 2026

Deep brain stimulation for clozapine-resistant schizophrenia: a systematic review of target-specific outcomes and stereotactic technical considerations.

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Systematic review investigates deep brain stimulation outcomes in clozapine-resistant schizophrenia, suggesting potential benefits amidst challenges.

Examine the outcomes of deep brain stimulation in patients with clozapine-resistant schizophrenia.
Conducted a systematic review following PRISMA guidelines
Searched seven databases until January 31, 2025
Included clinical studies focusing on DBS in treatment-resistant schizophrenia
Identified seven studies involving 21 patients
Reported PANSS total score changes ranging from 11% to 85.7%
Surgical complications occurred in 14.2% of patients, including infection and hemorrhage

Armando et al. (2026) studied this question.

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Systematic review investigates deep brain stimulation outcomes in clozapine-resistant schizophrenia, suggesting potential benefits amidst challenges.