Population
Adult feline myocardium (ex vivo and in vivo), papillary muscles, and isolated contracting cardiac myocytes
Comparison
Hemodynamic pressure overloading and myocardial… vs Normal perfusion pressures and unstretched…
Design
Preclinical
Follow-up
up to 60 minutes
Key result
Hemodynamic pressure overloading in adult feline myocardium induced de novo TNF-alpha mRNA expression within 30 minutes and protein production within 60 minutes, depressing myocyte cell motion.
Authors
Loading...
May implicate TNF-α in load-induced contractile impairment; leaves open its role and targetability in human HF.
This study provides initial evidence that adult mammalian myocardium produces biologically active TNF-alpha in response to hemodynamic pressure overloading, contributing to depressed myocyte contractility.
Kapadia et al. (1997) studied Hemodynamic pressure overloading. Hemodynamic pressure overloading vs. Normal perfusion pressures / unstretched myocardium was evaluated on TNF-alpha mRNA and protein biosynthesis. Hemodynamic pressure overloading in adult feline myocardium induced de novo TNF-alpha mRNA expression within 30 minutes and protein production within 60 minutes, depressing myocyte cell motion.