Key result
Direct-acting vasodilators such as hydralazine and minoxidil effectively lower blood pressure by dilating resistance arterioles, but require concomitant sympathetic inhibitors and diuretics.
Direct-acting vasodilators are effective for specific hypertensive conditions and severe left ventricular failure, though their use is often limited by adverse effects like reflex tachycardia and fluid retention.
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Requires concomitant sympathetic inhibitors and diuretics to counter reflex effects; leaves open their integration with contemporary regimens.
Cohn et al. (2011) conducted a review in Hypertension and severe left ventricular failure. Direct-acting vasodilators (hydralazine, minoxidil, sodium nitroprusside, nitrates) was evaluated. Direct-acting vasodilators such as hydralazine and minoxidil effectively lower blood pressure by dilating resistance arterioles, but require concomitant sympathetic inhibitors and diuretics.
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