What does this research mean for the field?

Right ventricular action potential duration is significantly prolonged and dispersion of repolarization is enhanced in failing human hearts compared with nonfailing hearts, contributing to arrhythmia susceptibility. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 6, 2012AJP Heart and Circulatory PhysiologyOpen Access

Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Heart Failure (n=10). Intervention: Failing human heart (Heart Failure) vs. Nonfailing human heart. Primary outcome: Right ventricular action potential duration (APD) at basic cycle length ≥2,000 ms (p=<0.05).

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Key result

Right ventricular action potential duration was significantly prolonged in failing human hearts compared with nonfailing hearts (560 vs. 448 ms), contributing to arrhythmia susceptibility.

Authors

QLQing LouHospital of the University of Pennsylvania DJDeborah JanksOakland University KHKatherine M. HolzemUniversity of Wisconsin–Madison

Discussion

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Implication

May elevate arrhythmia risk in HF; extends electrophysiological mechanisms but leaves open clinical translation.

Study Design

Type

Observational (n=10)

Multicenter

PICO

Population

Heart Failure (n=10)

Intervention / Comparator

Failing human heart (Heart Failure) vs Nonfailing human heart

Primary Outcome

Right ventricular action potential duration (APD) at basic cycle length ≥2,000 ms, p=<0.05

Main Result

Absolute Event Rate: 560% vs 448%

p-value: p=<0.05

Limitations

The etiology of HF, its duration, and medical treatment were varied and uncontrolled.
Lack of access to clinical data due to the deidentified tissue protocol.
Other mechanisms might also contribute to the dispersion of repolarization, such as heterogeneity of innervation.
The isolated tissue preparations were mechanically unloaded due to surgical opening and application of blebbistatin.
The failing human hearts were all in the end stage of HF, so results might not apply to earlier stages.

Cite This Study

Lou et al. (2012) conducted an observational in Heart Failure (n=10). Failing human heart (Heart Failure) vs. Nonfailing human heart was evaluated on Right ventricular action potential duration (APD) at basic cycle length ≥2,000 ms (p=<0.05). Right ventricular action potential duration was significantly prolonged in failing human hearts compared with nonfailing hearts (560 vs. 448 ms), contributing to arrhythmia susceptibility.

synapsesocial.com/papers/6a1c840e973ffece4bc3ed1e https://doi.org/10.1152/ajpheart.00457.2012

Topics

Heart transplantation Heart failure HFrEF treatment

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Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Limitations

Cite This Study

Topics

Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider