Population
Patients with arterial hypertension
Comparison
Antihypertensive therapy vs Placebo
Design
Review
Authors
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Trial biases may underestimate long-term antihypertensive benefits; leaves open precise effect sizes in broader populations.
The true cardiovascular benefits of antihypertensive therapy are likely greater than those demonstrated in randomized trials due to inherent methodological limitations such as crossover and low-risk patient recruitment.
Linjer et al. (1997) studied this question.
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