P1 and P3 proteins of influenza virus are required for complementary RNA synthesis
Population
Influenza A/WSN virus temperature-sensitive (ts) mutant groups defective in complementary RNA synthesis
Design
Preclinical
Authors
Discussion
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Member takes
Implication
P1/P3 proteins represent potential influenza antiviral targets in animal models; leaves open translation to human therapeutics.
Structured PICO
P
Population
Influenza A/WSN virus temperature-sensitive (ts) mutant groups defective in complementary RNA synthesis
I
Intervention
RNA analysis of recombinants having a ts+ phenotype derived from the mutants and HK virus
O
Outcome
Identification of defective genes and requirement of P1 and P3 proteins for complementary RNA synthesis
P1 and P3 proteins are essential for complementary RNA synthesis in the influenza virus.
Cite This Study
Palese et al. (1977) studied this question.