Why the study?
Does nebivolol reduce blood pressure with better tolerability compared to amlodipine in elderly patients with mild to moderate essential arterial hypertension?
Population
168 elderly patients (aged ≥ 65 years) with mild to moderate essential arterial hypertension
Comparison
Nebivolol 2.5-5 mg daily for 12 weeks vs Amlodipine 5-10 mg daily for 12 weeks
Design
RCT, randomized, parallel-group, double-blind
Follow-up
12 weeks
Authors
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Nebivolol may be preferred over amlodipine in elderly hypertensives for similar efficacy with fewer adverse events; reinforces its role as a first-line option.
Does nebivolol reduce blood pressure with better tolerability compared to amlodipine in elderly patients with mild to moderate essential arterial hypertension?
Nebivolol and amlodipine demonstrate similar antihypertensive efficacy in elderly patients, but nebivolol is associated with fewer drug-related adverse events such as headache and ankle edema.
Mazza et al. (2002) studied this question.
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