Population
coarcted and sham-coarcted rats
Comparison
development of coarctation hypertension vs sham-coarcted rats
Design
Preclinical
Follow-up
10 days
Authors
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These rat model findings warrant no change in clinical hypertension care; leaves open baroreflex roles in disease progression for human studies.
In a rat model of coarctation hypertension, baroreceptor reflex sensitivity for both bradycardia and tachycardia is progressively impaired during the development of hypertension.
Michelini et al. (1992) studied this question.
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