Why the study?
Does Western equine encephalitis virus infection cause myocarditis and electrocardiographic abnormalities in mice?
Population
Adult mice infected with Western equine encephalitis virus; and 11 persons with acute WEE virus infections…
Design
Preclinical
Follow-up
5 days
Authors
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WEE myocarditis in mice; leaves open human cardiac involvement and requires clinical confirmation before any practice implications.
Does Western equine encephalitis virus infection cause myocarditis and electrocardiographic abnormalities in mice?
Demonstration of necrotizing myocarditis in WEE virus-infected mice suggests the potential for cardiac involvement in human alphavirus infections.
Monath et al. (1978) studied this question.
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