Short-term inhibition of the Na–H exchanger limits acidosis and reduces ischemic injury in the rat heart

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Why the study?

Does short-term inhibition of the Na-H exchanger with EIPA reduce ischemic injury in isolated perfused rat hearts?

Structured PICO

Does short-term inhibition of the Na-H exchanger with EIPA reduce ischemic injury in isolated perfused rat hearts?

Population

Isolated perfused rat hearts

Intervention

Ethylisopropylamiloride (EIPA, 3 micro M) for 40 min, followed by 10 min of EIPA-free perfusate and 30 min of global ischemia

Comparator

Hearts perfused with either glucose alone (CTL) or EIPA 3 micro M for 10 min before ischemia (EIPA)

Outcome

Ischemic injury measured using creatine kinase (CK) release on reperfusionsurrogate

Short-term inhibition of the Na-H exchanger with EIPA prior to ischemia reduces ischemic injury and alters pH regulation in isolated rat hearts.

No takes yet. Share an insight, caveat, or question.

Should not change clinical practice; leaves open translation of Na-H exchanger inhibition to human ischemia.

Saul Schaefer (1997) studied this question.

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